Table 4. Histological analysis of infarct area in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 7 days and 28 days after MI.
7 Days after MI |
28 Days after MI |
|||
---|---|---|---|---|
Control (n=15) | AdLDLr (n=15) | Control (n=21) | AdLDLr (n=22) | |
Capillary density (number mm−2) | 490±26 | 520±28 | 290±17#### | 370±22**#### |
Collagen deposition (% of infarct area) | 29±1.4 | 28±1.9 | 50±1.9#### | 49±1.7#### |
Leukocyte infiltration (number mm−2) | 4400±260 | 3800±230 | 1200±110#### | 1100 ± 92#### |
Myofibroblast infiltration (% of infarct area) | 4.4±0.51 | 4.3±0.37 | 1.2±0.17#### | 0.80±0.094#### |
Abbreviations: AdLDLr, adenoviral LDLr; MI, myocardial infarction; LDLr, LDL receptor.
**P<0.01 for comparison of control versus AdLDLr-treated mice.
####P<0.0001 for comparison of day 7 versus day 28 after MI.
Data are expressed as means±s.e.m.