Table 5. Hemodynamic parameters in control and AdLDLr-treated female C57BL/6 LDLr−/− mice 28 days after sham operation or MI.
| Non-infarcted |
28 Days after MI |
||
|---|---|---|---|
| Control | Control | AdLDLr | |
| Left ventricle | |||
| Number of mice | 6 | 16 | 18 |
| Mean pressure (mm Hg) | 49±1.1 | 44±2.5 | 49±2.7 |
| Peak systolic pressure (mm Hg) | 120±2.8 | 98±3.5§§ | 110±2.9** |
| End-diastolic pressure (mm Hg) | 1.1±0.94 | 6.3±2.0§ | 5.6±1.7§ |
| Peak dP/dtmax (mm Hg ms–1) | 15±0.76 | 11±0.59§§ | 12±0.44*§§ |
| Peak dP/dtmin (mm Hg ms–1) | −12±1.0 | −7.4±0.48§§§§ | −8.7±0.32*§§ |
| Tau (ms) | 4.0±0.22 | 7.0±0.74§§§ | 6.3±0.46§§§ |
| Heart rate (b.p.m.) | 640±21 | 600±19 | 600±12 |
| Aorta | |||
| Number of mice | 7 | 22 | 22 |
| Mean pressure (mm Hg) | 94±3.0 | 79±2.6§§ | 90±2.1** |
| Peak systolic pressure (mm Hg) | 110±3.4 | 96±2.6§§ | 110±2.5* |
| Peak diastolic pressure (mm Hg) | 79±3.0 | 64±2.8§§ | 77±1.9*** |
Abbreviations: AdLDLr, adenoviral LDLr; MI, myocardial infarction; LDLr, LDL receptor.
*P<0.05,**P<0.01,***P<0.001 for comparison of control versus AdLDLr-treated mice.
§P<0.05, §§P<0.01, §§§P<0.001, §§§§P<0.0001 for comparison versus non-infarcted mice.
Data are expressed as means±s.e.m.