Table 4.
Expression (mRNA) ratio (studied genes/β-actin) for tight junction and protein kinase C in terminal ileum tissues of each experimental group (mean ± SD)
Genes | Group I | Group II | Group III | Group IV | Group V |
Occludin | 2.5458 ± 0.2260 | 0.4881 ± 0.0426a | 0.9792 ± 0.2066 | 1.4902 ± 0.0720c | 1.8976 ± 0.1049 |
ZO-1 | 7.2420 ± 0.4025 | 0.9541 ± 0.1629a | 1.4064 ± 0.1632 | 2.8843 ± 0.1641c | 4.0727 ± 0.2059 |
Claudin-1 | 1.9751 ± 0.0615 | 0.0546 ± 0.0336a | 0.4741 ± 0.0897 | 0.9092 ± 0.1295c | 1.4793 ± 0.2119 |
Claudin-4 | 42.8680 ± 7.5291 | 0.3546 ± 0.0916a | 5.3245 ± 1.1801 | 8.7719 ± 1.4659c | 15.9592 ± 2.8815 |
JAM-A | 3..3259 ± 0.3704 | 0.4712 ± 0.1107a | 0.9456 ± 0.1101 | 1.6270 ± 0.2153c | 2.1006 ± 0.1534 |
PKC | 6.6958 ± 0.9349 | 1.7959 ± 0.2992a | 2.8281 ± 0.3287 | 3.7178 ± 0.5110c | 4.7235 ± 0.4958 |
P < 0.05 vs Group III;
P < 0.05 vs Group V. Group I: Sham-operation; Group II: Bile duct ligation (BDL); Group III: BDL + L. plantarum; Group IV: BDL + internal biliary drainage (IBD); Group V: BDL + IBD + L. plantarum. JAM-A: Junction adhesion molecule-A; PKC: Protein kinase C.