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. 2012 Aug 17;150(4):673–684. doi: 10.1016/j.cell.2012.06.045

Figure 4.

Figure 4

Histological Analysis of the Antispermatogenic Effects of JQ1

(A and B) Histology of stage VII seminiferous tubules of testes of 6-week-old mice treated with (A) vehicle control or (B) JQ1 (50 mg/kg QD) from 3–6 weeks of age (40× magnification). Red arrows indicate intertubular Leydig cell islands.

(C and D) Histology of stage VII seminiferous tubules of 12-week-old mice treated with (C) control or (D) JQ1 (50 mg/kg QD) from 6–12 weeks. A large mass of sloughed epithelium is observed in the lumen of the tubule in (D).

(E–H) Histological analysis of testis tubules from 12-week-old mice treated with vehicle control (E, 40×; G, 100×) or JQ1 (50 mg/kg BID) (F, 40×; H, 100×) for 3 weeks. Whereas the stage VII tubules of the control show an abundance of round spermatids (red arrowheads, G), only a few normal appearing round spermatids are evident in (H) after JQ1 treatment. Abnormal spermatids with large nuclei and abundant cytoplasm (blue arrowheads) and symplasts (black arrows in F and H) are also observed.