TABLE 1.

Characteristics of Patients at the Time of False Negative ¹²³I-MIBG SPECT

Patient	Age (yr)/Sex	Reason for consult at NIH	Hypersecretion in Plasma		Hypersecretion in Urine		Gene Mutation
			Meta-nephrines	Cate-cholamines	Meta-nephrines	Cate-cholamines
1	13/F	P	NMN, MN	NE, E, DA	--	--	Apparently sporadic
2	47/F	P	NMN, MN	E	NMN, MN, T	None	RET
3	51/F	P	NMN, MN	NE, E	NMN, MN, T	NE, E	Apparently sporadic
4	61/M	P	None	DA	--	--	SDHB
5	49/F	P	NMN	NE	NMN, T	NE	Apparently sporadic
6	46/F	P	NMN, MN	None	--	--	Apparently sporadic
7	36/F	New P	NMN	NE	NMN, T	NE	SDHB
8	40/F	R	NMN	NE	NMN, T	NE, DA	Apparently sporadic
9	55/M	Met + New P	NMN	NE, DA	NMN, T	NE	Neg for SDHx
10	48/F	Met + New P	NMN	NE, DA	NMN, T	NE, DA	SDHB
11	42/F	Met + New P	NMN	NE, DA	NMN, T	NE	SDHB
12	36/F	Met	NMN	NE	NMN, T	NE	SDHB
13	32/M	Met	NMN, MN	None	None	None	Apparently sporadic
14	47/F	Met	None	None	--	--	SDHB
15	43/F	Met	NMN	NMN	NMN, T	None	SDHB
16	34/M	Met	NMN	NE, DA	--	--	SDHB
17	37/M	Met	NMN	NE, DA	--	--	SDHB
18	43/F	Met	None	None	--	--	SDHB
19	45/F	Met	NMN	NE	None	NE	Apparently sporadic
20	33/M	Met	None	None	--	--	SDHB
21	22/F	Met	NMN	NE	NMN, T	NE	Apparently sporadic

Adr: adrenal gland; DA: dopamine; E: epinephrine; F: female; M: male; MN: metanephrine; Met: metastasis; NE: norepinephrine; Neg: Negative; NMN: normetanephrine; P: primary tumor; R: recurrence; RET: rearranged during transfection; SDHB: succinate dehydrogenase subunit B; SDHD: succinate dehydrogenase subunit D; T: total metanephrines; VHL: von Hippel-Lindau

--: not available