Table 4. Pharmacokinetic parameters by dose group.
| Parameter Statistic |
PF-04523655 (μg) |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 50 | 100 | 200 | 400 | 670 | 1000 | 1500 | 2250 | 3000 | |
| Cmax (ng/ml) | |||||||||
| N | 0 | 1 | 0 | 2 | 3 | 2 | 3 | 3 | 3 |
| Min | NA | 0.26 | NA | 0.41 | 0.18 | 0.14 | 0.35 | 1.10 | 0.77 |
| Median | NA | 0.26 | NA | 1.78 | 0.40 | 0.42 | 1.25 | 2.90 | 1.24 |
| Max | NA | 0.26 | NA | 3.15 | 0.41 | 0.70 | 7.48 | 4.57 | 2.13 |
| Tmax(h) | |||||||||
| N | 0 | 1 | 0 | 2 | 3 | 2 | 3 | 3 | 3 |
| Min | NA | 4 | NA | 1 | 1 | 1 | 1 | 4 | 1 |
| Median | NA | 4 | NA | 2.5 | 4 | 2.5 | 4 | 4 | 4 |
| Max | NA | 4 | NA | 4 | 4 | 4 | 24 | 4 | 4 |
| AUClast (ng/h/ml) | |||||||||
| N | 0 | 0 | 0 | 1 | 2 | 1 | 2 | 3 | 3 |
| Min | NA | NA | NA | 6.06 | 3.58 | 10.14 | 6.59 | 15.72 | 10.95 |
| Median | NA | NA | NA | 6.06 | 6.13 | 10.14 | 33.14 | 42.76 | 20.23 |
| Max | NA | NA | NA | 6.06 | 8.68 | 10.14 | 59.68 | 63.30 | 62.43 |