Table 2.
Correlation of cathepsin D expression at MTB with clinico-pathological features.
| Clinico-pathological parameters | No. of cases (%)1 | neg/weak (%)2 | Moderate (%)2 | Strong (%)2 | P value3 |
|---|---|---|---|---|---|
| Age | 0.139 | ||||
| <65 | 35 (29) | 14 (40) | 14 (40) | 7 (20) | |
| ≥65 | 84 (71) | 50 (60) | 21 (25) | 13 (15) | |
| Gender | 0.586 | ||||
| F | 59 (50) | 30 (51) | 17 (29) | 12 (20) | |
| M | 60 (50) | 34 (57) | 18 (30) | 8 (13) | |
| Tumor location | 0.072 | ||||
| Colon | 82 (69) | 49 (60) | 19 (23) | 14 (17) | |
| Rectum | 37 (31) | 15 (41) | 16 (43) | 6 (16) | |
| Histological type | 0.177 | ||||
| Nonmucinous | 102 (86) | 52 (51) | 33 (32) | 17 (17) | |
| Mucinous | 16 (14) | 12 (75) | 2 (13) | 2 (13) | |
| Histological grade | 0.211 | ||||
| High grade | 95 (81) | 47 (50) | 31 (33) | 17 (18) | |
| Low grade | 23 (19) | 16 (70) | 4 (17) | 3 (13) | |
| Vascular invasion | 0.400 | ||||
| Negative | 90 (76) | 51 (57) | 26 (29) | 13 (14) | |
| Positive | 29 (24) | 13 (45) | 9 (31) | 7 (24) | |
| Perineural invasion | 0.839 | ||||
| Negative | 109 (92) | 59 (54) | 32 (29) | 18 (17) | |
| Positive | 9 (8) | 4 (44) | 3 (33) | 2 (22) | |
| TNM stages | 0.064 | ||||
| I | 20 (17) | 12 (60) | 5 (25) | 3 (15) | |
| II | 42 (36) | 27 (64) | 10 (24) | 5 (12) | |
| III | 34 (29) | 18 (53) | 13 (38) | 3 (9) | |
| IV | 21 (18) | 7 (33) | 6 (29) | 8 (38) | |
| Distant metastasis | 0.038 ∗ | ||||
| No | 89 (75) | 52 (58) | 27 (30) | 10 (11) | |
| Yes | 29 (25) | 12 (41) | 8 (28) | 9 (31) | |
| Nodal status | 0.358 | ||||
| Negative | 66 (58) | 38 (58) | 16 (24) | 12 (18) | |
| Positive | 47 (42) | 24 (51) | 17 (36) | 6 (13) | |
| Depth of invasion | 0.935 | ||||
| T1/T2 | 23 (20) | 13 (57) | 7 (30) | 3 (13) | |
| T3/T4 | 93 (80) | 51 (55) | 27 (29) | 15 (16) | |
| 5-year recurrence4 | 0.090 | ||||
| Recurrence free | 58 (79) | 40 (69) | 14 (24) | 4 (7) | |
| Recurrence | 15 (21) | 6 (40) | 6 (40) | 3 (20) |
1Percentage of the column.
2Percentage of the row.
3 P value based on Pearson's χ 2 test; ∗ P ≤ 0.05.
4Presence or absence of local or distant metachronous recurrence within 5-year followup.
∗Significant correlation between expression of cathepsin D at MTB with distant metastasis.