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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 Mar 14;1(5):609–628. doi: 10.1002/wdev.44

Figure 2. Pancreatic specification is unaltered in embryos lacking either Pdx1 or Ptf1a.

Figure 2

Sagittal sections from E10.5 Pdx1 null (A) and wildtype littermate (B), as well as Ptf1a null (C) and wildtype littermate (D) embryos were stained by immunofluorescence with antibodies against the transcription factor FOXA (demarking endoderm) and the hormone glucagon (identifying the pancreatic domain). In both null embryos, the region fated to become the dorsal pancreas (dp) is present, contains glucagon-expressing cells, and appears similar in both the null and wildtype. stm, septum transversum mesenchyme. DAPI marks all nuclei. 20X