Table 1.
UTX-deficiency leads to embryonic lethality for female embryos
| Males (% of males) |
Females (% of females) |
Reabsorbed (% of total) | Total | |||||
| Age | UtxWt | UtxKO | Subtotal | UtxKO/Wt | UtxKO/KO | Subtotal | ||
| E8.5 | 3 (60) | 2 (40) | 5 | 4 (57) | 3 (43) | 7 | 0 | 12 |
| E9.5 | 4 (50) | 4 (50) | 8 | 6 (50) | 6 (50) | 12 | 0 | 20 |
| E10.5 | 11 (42) | 15 (58) | 26 | 10 (50) | 10 (50) | 20 | 0 | 46 |
| E11.5 | 9 (53) | 8 (47) | 17 | 8 (75) | 4 (25) | 12 | 2 (6) | 41 |
| E12.5 | 4 (57) | 3 (43) | 7 | 6 (100) | 0 (0) | 6 | 8 (38) | 21 |
| E13.5 | 13 (65) | 7 (35) | 20 | 5 (100) | 0 (0) | 5 | 8 (24) | 33 |
| 3 wk | 79 | 15 | 94 | 61 | 0 | 61 | N/A | 155 |
| Observed ratios | 1 | 0.2 | 0.8 | 0 | ||||
| Expected ratios | 1 | 1 | 1 | 1 | ||||
This table provides a summary of observed progeny at different developmental time points obtained from matings between UtxFlx males with a germ-line Cre deleter (Ncre) and UtxKO/Wt females. Expected ratios and observed ratios are provided at the bottom with the latter calculated from the progeny genotyped at 3 wk of age. The timing of gestation was determined based on the morning of the appearance of a plug as being E0.5.