Figure 1.

The metabolism of icaritin and calycosin in zebrafish embryos and larvae. The proposed routes of how icaritin and calycosin are metabolized in zebrafish embryos and larvae are summarized and some drug metabolism enzymes are identified by omics approach. The process and the corresponding gene are shown in each colored box. Glc: glycosylated group; Glu: glucuronidated group; Xyl: xylated group; SO₃: sulfonated group; Xylt1: Xylosyltransferase 1; Ugt1a1, Ugt1ab: UDP-glucuronosyltransferase.