Figure 5.

MPTP induces DA neuron loss in zebrafish. (a) Representative picture of anti-TH whole mount immunostaining. TH⁺ neurons in diencephalic region were indicated by bracket, dorsal view. L-dep, L-deprenyl (selegiline), a selective MAO-B inhibitor, was used as positive control. (b) Counting of TH⁺ neuron. (c) Relative fold change of th gene expression as compared to control, MPTP downregulated th gene expression. ^# P < 0.05 and ^## P < 0.01 compared with untreated control. *P < 0.05 and **P < 0.01 compared with MPTP treated alone.