Table 1.
Characteristics, haemodynamics and Cardiopulmonary exercise parameters at baseline of the overall group (n = 116) and between patients with PAH (n = 85) and those with CTEPH (n = 31)
| |
Overall |
PAH |
CTEPH |
p |
|---|---|---|---|---|
| (n = 116) | (n = 85) | (n = 31) | ||
| Age (years) |
61.5 ± 1.5 |
59.9 ± 1.9 |
66.4 ± 2.0 |
p = 0.064 |
| Sex (% female) |
66 |
70 |
55 |
ns |
| BMI (kg/m2) |
25.8 ± 0.5 |
25.7 ± 0.6 |
26.2 ± 0.7 |
ns |
| PAP, mmHg |
39.9 ± 2.5 |
40.5 ± 1.7 |
38.3 ± 3.1 |
ns |
| CI, L*min-1*m-2 |
2.48 ± 0.07 |
2.58 ± 0.08 |
2.22 ± 0.11 |
p = 0.021 |
| PVR, dynes * s * cm-5 |
648.2 ± 40.2 |
647.9 ± 45.1 |
648.9 ± 87.5 ns |
|
| RAP, mmHg |
7.28 ± 0.49 |
7.01 ± 0.56 |
8.07 ± 1.00 |
ns |
| W, watts |
56.2 ± 3.1 |
55.2 ± 3.7 |
59.1 ± 5.5 |
ns |
| VO2, ml/min/kg |
14.4 ± 0.7 |
14.5 ± 0.8 |
14.1 ± 1.2 |
ns |
| AT, ml/min/kg |
9.53 ± 0.40 |
9.56 ± 0.48 |
9.45 ± 0.72 |
ns |
| O2 pulse, ml/min/beat |
8.98 ± 0.36 |
8.71 ± 0.40 |
9.72 ± 0.81 |
ns |
| Ve/VO2 - AT |
41.1 ± 1.1 |
40.9 ± 1.2 |
41.8 ± 2.3 |
ns |
| Ve/VCO2 - AT |
47.2 ± 1.1 |
47.0 ± 1.2 |
47.8 ± 2.5 |
ns |
| AaDO2 (peak exercise) |
mmHg 49.3 ± 1.6 |
51.6 ± 1.9 |
43.2 ± 2.9 |
p = 0.019 |
| a-et CO2, mmHg |
5.7 ± 0.5 |
5.2 ± 0.5 |
7.0 ± 1.0 |
ns |
| Ve/VCO2 slope | 46.9 ± 2.0 | 46.6 ± 2.3 | 47.9 ± 3.9 | ns |
W = work capacity.
VO2 = peak oxygen uptake.
AT = anaerobic threshold.
O2 pulse = oxygen pulse.
Ve/VO2 = oxygen equivalent at anaerobic threshold.
Ve/VCO2 = carbon dioxide equivalent at anaerobic threshold.
AaDO2 = alveolar-arterial oxygen difference at peak exercise.
a-et CO2 = arterial-endexpiratory carbon dioxide difference at peak pexercise.
Ve – VCO2 slope = slope of minute ventilation versus carbon dioxide output.