Skip to main content
. Author manuscript; available in PMC: 2012 Aug 16.
Published in final edited form as: J Immunol. 2010 Mar 3;184(7):3326–3330. doi: 10.4049/jimmunol.0904189

FIGURE 1.

FIGURE 1

M. tuberculosis infected IL-1β−/− mice display acute mortality and elevated bacterial loads. Survival of TLR2/TLR9−/− (dark gray), TRIF/MyD88−/− (green), MyD88−/− (blue), IL-18−/− (purple), IL-1β−/− (red), IL-1R1−/− (black), and C57BL6 WT (dotted black line, white circle) mice after low dose aerosol exposure to H37Rv. Vertical dotted line in lower panel represents survival of IL-1β−/− mice (A). Data are representative of at least two independent experiments each involving 5–12 mice per group. At 4 wk p.i. bacterial loads were measured in BALF and lung suspensions from the strains indicated (B). Data are pooled from 3–6 independent experiments. C, Representative H&E-stained sections from lungs of C57BL6 WT, MyD88−/− and IL-1β−/− mice are shown at 4 wk p.i. Original magnifications ×50 and ×400. D, Presents % lung affected, mean granuloma sizes, as well as the relative number of acid fast bacilli and degree of necrosis scored blindly.