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Stress up-regulates HIF-1α expression in skin but not in tongue wounds. Mice were subjected to restraint stress for 3 cycles as described in Materials & Methods. Six and 24 hrs after wounding occurred, wounded tissues from skin and tongue were harvested, and real-time PCR was utilized to analyze mRNA expression of HIF-1α. *p < 0.001 compared with control group. Con: control. Str: stressed.
