Figure 1.

A schematic showing the evolving notion of biomarker utility from the inception of the concept of biomarkers to their use in medical research. This schema acknowledges that the discovery of diagnostic biomarkers is likely to also allow the separation of the different-component disorders in the syndrome of schizophrenia and that more tailored treatment of these component disorder will be possible. Hence diagnostic biomarkers, to a greater or lesser extent, are also likely to be treatment biomarkers.