Figure 2. 12-LOX upregulates HIF-1α mRNA in prostate cancer cells under hypoxia.
Northern blotting was performed to measure the abundance of HIF-1α message in nL-8 and neo cells as outlined in “materials and methods”, using total mRNA isolated from nL-8 and neo cells incubated under hypoxic conditions for 6 h. Shown here is a representative result from two independent experiments.