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. 2012 Aug 16;7(8):e43437. doi: 10.1371/journal.pone.0043437

Figure 9. JAK2 inhibitor-resistant residues mapped to the crystal structure bound to JAK Inhibitor-I.

Figure 9

The JAK2 kinase domain in complex with JAK Inhibitor-I has been previously published [47]. (A) The face of the kinase domain displays three of the nine residues with identified mutations: E864, G935, R975. (B) Rotated 90 degrees counter-clockwise, three more residues are visible: N909, M929, R1127. (C) Rotated 90 degrees clockwise from 9a are the final three residues: V881, Y918, P1057. (D) The kinase domain is displayed, the n-lobe in orange and c-lobe in yellow. G935 is displayed in red. (E) The kinase domain binding pocket is displayed, G935 in red. (F) The kinase domain binding pocket is displayed, R935 mutation is in red.