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. 2012 Aug 16;7(8):e43304. doi: 10.1371/journal.pone.0043304

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© 2012 Lin et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Luteolin induces the up-regulation of miR-132, which may serve as a mediator for neurite outgrowth through the activation of cAMP/PKA- and ERK-dependent CREB signaling pathways in PC12 cells. In addition, ERK- or PKC-dependent but CREB/miR-132-independent pathways may also partially contribute to the mediation of neurite outgrowth by luteolin in PC12 cells.