Table 1. Epistasis analysis between the insulin and RAS/MAPK pathways.
| genotype | Induction±SE | % Vul | % Muv | n | |
| 1 | let-60(gf) | 4.16±0.05 | 0.00 | 79.1 | 283 |
| 2 | daf-2(rf); let-60(gf) | 3.24±0.11*** (1) | 0.00 | 19.3 | 31 |
| 3 | daf-18(lf) let-60(gf) | 4.99±0.05*** (1) | 0.00 | 96.4 | 221 |
| 4 | let-23(rf) | 0.55±0.08 | 93.8 | 0.00 | 129 |
| 5 | let-23(rf); daf-18(lf) | 1.90±0.10*** (4) | 63.9 | 6.8 | 133 |
| 6 | lin-2(lf) | 1.34±0.19 | 73.8 | 0.00 | 42 |
| 7 | daf-18(lf); lin-2(lf) | 2.50±0.12*** (6) | 35.5 | 1.7 | 59 |
| 8 | age-1(lf); daf-18(lf) let-60(gf) | 4.61±0.08*** (1) | 0.00 | 94.7 | 113 |
| 9 | age-1(lf); daf-18(lf); lin-2(lf) | 2.15±0.16*** (6) | 53.1 | 6.1 | 49 |
| 10 | daf-2(rf); daf-18(lf) let-60(gf) | 4.40±0.17(1) | 0.00 | 88.0 | 25 |
| 11 | let-23(rf); akt-1(gf) | 0.36±0.13(4) | 94.9 | 0.00 | 39 |
| 12 | daf-18(lf) let-60(gf); akt-1(lf) | 4.80±0.29(3) | 0.00 | 80 | 15 |
| 13 | daf-16(lf); let-60(gf) | 4.18±0.11(1) | 0.00 | 77.5 | 80 |
| 14 | age-1(lf); let-60(gf) † | 4.08±0.06(1) | 0.00 | 76.2 | 164 |
| 15 | age-1(lf); daf-16(lf); let-60(gf) | 3.62±0.15** (1) | 0.00 | 54.1 | 24 |
SE indicates the standard error of the mean. % Vul indicates the fraction of animals with less than three induced VPCs. % Muv indicates the fraction of animals with more than three induced VPCs. Induction indicates the average number of induced VPCs per animal.
**
indicates a p-value≤0.005;
***
indicates a p-value≤0.0005. Numbers in brackets indicate the row against which a t-test was performed. Alleles used: LG I: daf-16(mu86), LG II: age-1(mg44), let-23(sy1), LG III: daf-2(e1370), LG IV: let-60(n1046), daf-18(ok480), LG V: akt-1(ok525lf), akt-1(mg144af), LG X: lin-2(n397).
†
F1 progeny of heterozygous age-1(lf)/+ parents.