Figure 3. seurat mutants exhibit lesions in igsf11.

(A) Meiotic mapping of the seurat^utr15e1 allele revealed a ∼210 kb critical genetic interval harboring several open reading frames of which only igsf11 exhibits ENU-induced lesions. Differences in numbers of individuals tested across markers reflect the absence of polymorphisms in some mapping families. (B) Schematic of inferred Igsf11 protein showing identified mutations and predicted domains. The lesion in the mapped allele, seurat^utr15e1, occurred in exon 4, whereas lesions in seurat^wp15e2 and seurat^wp15e3 were found in exon 2. S, predicted signal sequence; TM, predicted transmembrane domain; Ig (V-set), immunoglobulin V-set domain; Ig (I-set), immunoglobulin I-set domain.