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| NKT Cell Subset | Mouse | Human | |
| Type I | TCR | Vα14-Jα18; Vβ8.2/7/2 | Vα24-Jα18; Vβ11 |
| Subsets | CD4+, DN | CD4+, CD8+, DN | |
| Ligand | αGalCer | αGalCer | |
| Restriction | CD1d | CD1d | |
| NK receptors | NK1.1+/− | CD161+/− | |
| Type II | TCR | Vα3.2-Jα9 or Vα8; Vβ8 | Diverse |
| Subsets | CD4+, DN | CD4+, CD8+ | |
| Ligand | Sulfatide, lysosulfatide, lysophosphatidylcholine | Sulfatide, lysosulfatide, lysophosphatidylcholine | |
| Restriction | CD1d | CD1d | |
| NK receptors | NK1.1+/− | CD161+ |
