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. 2012 Aug 16;8(8):e1002908. doi: 10.1371/journal.pgen.1002908

Figure 8. Association of rs7120118 with HDL-C in More Than 100,000 Individuals.

Figure 8

Association of rs7120118 with HDL-C levels was examined using a published dataset from a study in more than 100,000 individuals [14] using LocusZoom [27] to plot the SNPs examined and imputed from 1000 Genomes Project dataset. A high level of LD is present within the locus, with at least 29 genes implicated with HDL. rs7120118 is indicated in purple (p = 1.297×10−14), with the SNPs in strongest LD marked in red. Although not statistically the lead SNP at this region, with the additional effects of this SNP on open chromatin, NR1H3 gene expression, and proximity to NR1H3, rs7120118 is represents a good functional candidate.