Table 1.
Demographic and clinical characteristics of subjects
| N=22 | |
|---|---|
| Mean age, years (SD; range) | 58 (6; 50 73) |
| % male | 86 (19/22) |
| % non-Hispanic white | 77 (17/22) |
| % Hispanic white | 5 (1/22) |
| % Asian | 9 (2/22) |
| % Native American | 5 (1/22) |
| % Native Hawaiian | 5 (1/22) |
| Mean years of education (SD; range) | 16 (2; 12–20) |
| HIV-associated parameters | |
| Mean years HIV-positive (SD; range) | 17 (2–26) |
| % on HAART | 95 (21/22) |
| % on protease inhibitor | 18 (4/22) |
| % with current CD4+ count >200 cells/µL | 100 (22/22) |
| % with undetectable HIV RNA viral load (<50 copies/mL) | 82 (18/22) |
| Mean self-reported lowest ever CD4 count, cells/µL (SD; range) | 210 (171; 1–450) |
| % with history of prior stimulant use | 64 (14/22) |
| Cerebrovascular risk factors | |
| Mean body mass index, kg/m (Wright et al. 2010) (SD) | 24 (3) |
| % with abdominal obesitya | 0 (0/22) |
| Mean waist circumference, cm (SD, range) | 91 (7; 76–102) |
| % with impaired glucose tolerance | 41 (9/22) |
| % with adult-onset diabetes mellitus | 18 (4/22) |
| % with hypertension | 45 (10/22)50 |
| Mean SBP, mmHg (SD, range) | 126 (18; 99–159) |
| Mean DBP, mmHg (SD, range) | 74 (10; 52–89) |
| % with fasting LDL≥100 mg/dL | 50 (11/22) |
| Mean fasting LDL, mg/dL (SD, range) | 112 (44; 52–226) |
| % with fasting triglycerides ≥ 150 mg/dL | 36 (8/22) |
| Mean fasting triglycerides, mg/dL (SD, range) | 169 (128; 36–341) |
| % with fasting HDL cholesterol <40 mg/dL in men or <50 mg/dL in women | 64 (14/22) |
| Mean fasting HDL cholesterol, mg/dL (SD; range) | 40 (19; 18–110) |
| % with metabolic syndrome | 32 (7/22) |
| % with past or present smoking history | 45 (10/22) |
| Mean pack years (SD, range) | 19 (11; 1–30) |
| % with at least one APOE e4 allele | 40 (9/22) |
| % with white matter hyperintensities on MRI | 36 (8/22) |
| Mean Beck Depression Inventory score (SD, range) | 7 (4, 1–15) |
APOE ε4 allele apolipoprotein epsilon 4 allele, DBP diastolic blood pressure, HAART highly active antiretroviral therapy, MI myocardial infarction, SBP systolic blood pressure, SD standard deviation
a
Abdominal obesity was defined as a waist circumference in men greater than 102 cm (40 in.) and in women greater than 88 cm (35 in.) (Detection et al. 2001)