Table 2.
Association of vascular risk factors and DTI parameters
| Abnormal glucose metabolisma | Hypertension | Dyslipidemia | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Present | Absent | FDR critical p value | Present | Absent | FDR critical p value | Present | Absent | FDR critical p value | |
| Caudate MD | 1.33 (0.65) | 1.14 (0.54) | 0.008 | 1.32 (0.63) | 1.19 (0.58) | NS | 1.31 (0.63) | 1.20 (0.58) | NS |
| Caudate FA | 0.19 (0.10) | 0.21 (0.11) | 0.002 | 0.20 (0.10) | 0.21 (0.11) | NS | 0.19 (0.10) | 0.21 (0.12) | NS |
| Hippocampus MD | 1.16 (0.27) | 1.01 (0.20) | NS | 1.15 (0.27) | 1.05 (0.23) | NS | 1.15 (0.26) | 1.05 (0.23) | NS |
| Hippocampus FA | 0.16 (0.08) | 0.19 (0.09) | 0.004 | 0.17 (0.08) | 0.18 (0.09) | NS | 0.17 (0.08) | 0.18 (0.09) | NS |
| Thalamus MD | 1.01 (0.47) | 0.92 (0.36) | NS | 1.02 (0.51) | 0.93 (0.35) | NS | 1.02 (0.47) | 0.93 (0.39) | NS |
| Thalamus FA | 0.29 (0.10) | 0.29 (0.09) | NS | 0.30 (0.10) | 0.29 (0.09) | NS | 0.28 (0.09) | 0.30 (0.09) | NS |
| Putamen MD | 0.75 (0.7) | 0.75 (0.06) | NS | 0.76 (0.06) | 0.74 (0.07) | NS | 0.76 (0.06) | 0.74 (0.07) | NS |
| Putamen FA | 0.25 (0.07) | 0.22 (0.07) | NS | 0.24 (0.07) | 0.25 (0.07) | NS | 0.24 (0.08) | 0.24 (0.06) | NS |
| Globus pallidus MD | 0.70 (0.14) | 0.65 (0.15) | NS | 0.69 (0.14) | 0.66 (0.15) | NS | 0.70 (0.14) | 0.65 (0.15) | NS |
| Globus pallidus FA | 0.37 (0.09) | 0.41 (0.09) | NS | 0.38 (0.08) | 0.39 (0.09) | NS | 0.37 (0.09) | 0.40 (0.08) | NS |
| Corpus callosum MD | 0.90 (0.17) | 0.90 (0.03) | NS | 1.02 (0.19) | 0.91 (0.03) | NS | 1.01 (0.19) | 0.91 (0.03) | NS |
| Corpus callosum FA | 0.42 (0.05) | 0.44 (0.03) | NS | 0.41 (0.05) | 0.45 (0.02) | NS | 0.43 (0.05) | 0.44 (0.02) | NS |
| Frontal lobe WM MD | 1.09 (0.32) | 1.02 (0.29) | NS | 1.10 (0.32) | 1.01 (0.29) | NS | 1.10 (0.33) | 1.02 (0.28) | NS |
| Frontal lobe WM FA | 0.20 (0.11) | 0.20 (0.12) | NS | 0.20 (0.11) | 0.20 (0.12) | NS | 0.20 (0.11) | 0.20 (0.12) | NS |
| Parietal lobe WM MD | 1.02 (0.36) | 0.96 (0.33) | NS | 1.02 (0.37) | 0.96 (0.33) | NS | 1.02 (0.36) | 0.97 (0.33) | NS |
| Parietal lobe WM FA | 0.20 (0.13) | 0.21 (0.13) | NS | 0.20 (0.12) | 0.21 (0.13) | NS | 0.20 (0.13) | 0.21 (0.13) | NS |
| Temporal lobe WM MD | 1.00 (0.35) | 0.92 (0.31) | NS | 1.00 (0.36) | 0.93 (0.31) | NS | 1.00 (0.35) | 0.93 (0.32) | NS |
| Temporal lobe WM FA | 0.18 (0.08) | 0.19 (0.09) | NS | 0.18 (0.08) | 0.19 (0.09) | NS | 0.18 (0.09) | 0.19 (0.09) | NS |
| Occipital lobe WM MD | 0.96 (0.26) | 0.89 (0.23) | NS | 0.95 (0.27) | 0.91 (0.23) | NS | 0.95 (0.26) | 0.91 (0.24) | NS |
| Occipital lobe WM FA | 0.17 (0.08) | 0.18 (0.09) | NS | 0.17 (0.08) | 0.17 (0.09) | NS | 0.17 (0.08) | 0.17 (0.09) | NS |
| Past or current tobacco use | Metabolic syndrome | At least one APOE e4 allele present | |||||||
| Present | Absent | FDR critical p value | Present | Absent | FDR critical p value | Present | Absent | FDR critical p value | |
| Caudate MD | 1.25 (0.59) | 1.26 (0.61) | NS | 1.33 (0.65) | 1.22 (0.58) | NS | 1.25 (0.60) | 1.26 (0.60) | NS |
| Caudate FA | 0.20 (0.11) | 0.20 (0.10) | NS | 0.20 (0.10) | 0.20 (0.11) | NS | 0.21 (0.11) | 0.19 (0.10) | NS |
| Hippocampus MD | 1.10 (0.24) | 1.10 (0.24) | NS | 1.16 (0.28) | 1.07 (0.23) | NS | 1.11 (0.26) | 1.09 (0.24) | NS |
| Hippocampus FA | 0.18 (0.08) | 0.17 (0.08) | NS | 0.16 (0.08) | 0.18 (0.08) | NS | 0.17 (0.08) | 0.17 (0.08) | NS |
| Thalamus MD | 0.98 (0.43) | 0.97 (0.42) | NS | 0.99 (0.46) | 0.97 (0.41) | NS | 0.98 (0.45) | 0.97 (0.41) | NS |
| Thalamus FA | 0.29 (0.09) | 0.30 (0.09) | NS | 0.30 (0.10) | 0.29 (0.09) | NS | 0.30 (0.10) | 0.29 (0.09) | NS |
| Putamen MD | 0.76 (0.06) | 0.74 (0.06) | NS | 0.75 (0.08) | 0.75 (0.06) | NS | 0.76 (0.06) | 0.74 (0.06) | NS |
| Putamen FA | 0.23 (0.07) | 0.25 (0.07) | NS | 0.26 (0.07) | 0.23 (0.07) | NS | 0.23 (0.07) | 0.25 (0.07) | NS |
| Globus pallidus MD | 0.67 (0.16) | 0.69 (0.13) | NS | 0.69 (0.15) | 0.67 (0.14) | NS | 0.70 (0.13) | 0.66 (0.15) | NS |
| Globus pallidus FA | 0.39 (0.10) | 0.38 (0.08) | NS | 0.39 (0.08) | 0.39 (0.09) | NS | 0.37 (0.08) | 0.40 (0.09) | NS |
| Corpus callosum MD | 0.96 (0.14) | 0.96 (0.15) | NS | 0.99 (0.19) | 0.94 (0.12) | NS | 0.96 (0.15) | 0.96 (0.14) | NS |
| Corpus callosum FA | 0.43 (0.05) | 0.43 (0.03) | NS | 0.43 (0.04) | 0.43 (0.04) | NS | 0.42 (0.05) | 0.44 (0.04) | NS |
| Frontal lobe WM MD | 1.05 (0.30) | 1.07 (0.32) | NS | 1.08 (0.33) | 1.05 (0.29) | NS | 1.07 (0.32) | 1.05 (0.30) | NS |
| Frontal lobe WM FA | 0.20 (0.12) | 0.20 (0.11) | NS | 0.20 (0.12) | 0.20 (0.11) | NS | 0.20 (0.11) | 0.20 (0.12) | NS |
| Parietal lobe WM MD | 0.98 (0.34) | 1.00 (0.35) | NS | 1.01 (0.37) | 0.99 (0.34) | NS | 1.00 (0.36) | 0.99 (0.34) | NS |
| Parietal lobe WM FA | 0.20 (0.13) | 0.21 (0.13) | NS | 0.20 (0.13) | 0.20 (0.13) | NS | 0.20 (0.13) | 0.20 (0.13) | NS |
| Temporal lobe WM MD | 0.96 (0.33) | 0.97 (0.34) | NS | 1.00 (0.37) | 0.95 (0.32) | NS | 0.97 (0.34) | 0.96 (0.33) | NS |
| Temporal lobe WM FA | 0.19 (0.09) | 0.19 (0.09) | NS | 0.18 (0.09) | 0.19 (0.09) | NS | 0.19 (0.09) | 0.18 (0.09) | NS |
| Occipital lobe WM MD | 0.92 (0.25) | 0.94 (0.25) | NS | 0.96 (0.27) | 0.92 (0.24) | NS | 0.93 (0.26) | 0.93 (0.24) | NS |
| Occipital lobe WM FA | 0.17 (0.08) | 0.17 (0.08) | NS | 0.17 (0.08) | 0.17 (0.08) | NS | 0.17 (0.08) | 0.17 (0.08) | NS |
MD values are expressed as 10−3
a
Abnormal glucose metabolism is defined as impaired fasting glucose, impaired glucose intolerance, or diabetes mellitus