Table 1.
Global Results from CNTNAP2 Association Analysis for Integrated Graph Theory Metrics for Whole Brain and Left and Right Hemispheres Separately
|
Global measures—recessive model | ||||
|---|---|---|---|---|
| Measure | Risk average (CC) | Nonrisk average (CT and TT) | b | p value |
| Whole brain | ||||
| CPL/λ | 17.5/10.09 | 17.67/10.16 | 0.17 | 0.0069 |
| MCC/γ | 8.57/13.74 | 8.35/14.27 | −0.2 | 0.21 |
| EGLOB | 6.16 | 6.1 | −0.049 | 0.032 |
| SW | 13.52 | 14 | 0.51 | 0.021 |
| MOD | 5.64 | 5.53 | −0.09 | 0.12 |
| Left hemisphere | ||||
| CPL/λ | 19.16/10.67 | 19.04/10.69 | −0.11 | 0.17 |
| MCC/γ | 6.13/17.64 | 6.16/17.10 | 0.038 | 0.54 |
| EGLOB | 5.6 | 5.51 | −0.09 | 0.00099 |
| SW | 16.57 | 15.96 | −0.6 | 0.00068 |
| MOD | 4.54 | 4.44 | −0.098 | 0.16 |
| Right hemisphere | ||||
| CPL/λ | 19.02/10.62 | 18.95/10.66 | −0.084 | 0.3 |
| MCC/γ | 6.35/17.37 | 6.36/17.24 | 0.02 | 0.79 |
| EGLOB | 5.64 | 5.56 | −0.077 | 0.0056 |
| SW | 16.33 | 16.14 | −0.17 | 0.31 |
| MOD | 4.39 | 4.28 | −0.11 | 0.079 |
Significant results are bolded. Results pass FDR correction for multiple comparisons across all 15 p values.
Whole-brain results showing CNTNAP2 SNP associations with graph theory measures of structural connectivity. Results are separated by hemisphere and are shown for the recessive model's SNP effect.
CPL, characteristic path length; MCC, mean clustering coefficient; EGLOB, global efficiency; SW, small-worldness, MOD, modularity; FDR, false discovery rate; SNP, single nucleotide polymorphism.