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. 2012 May 1;20(8):1610–1621. doi: 10.1038/mt.2012.82

Figure 6.

Figure 6

Lentiviral (LV)-N-sulfoglucosamine sulfohydrolase (SGSH) increases lifespan. A cohort of 6–10 mice from each group were kept to 92 weeks of age. Mice were sacrificed when they reached their humane end point, frequently caused due to urine retention. The estimated mean survival in weeks (w) for each group is shown at the bottom of the curve. The estimated mean survival was calculated by Mantel–Cox log rank pairwise comparisons, where data points were censored the largest survival time was used. Significant difference to mucopolysaccharidosis IIIA (MPS IIIA) is demonstrated with *P < 0.05, **P < 0.01, and ***P < 0.001 Groups were: wild-type (WT) untreated (WT), WT donor cells transduced with LV-SGSH into MPS IIIA recipients (LV-WT-HSCT), MPS IIIA donor cells transduced with LV-SGSH into MPS IIIA recipients (LV-IIIA-HSCT), WT to MPS IIIA (WT-HSCT) and MPS IIIA untreated (MPS IIIA). The copy number of the survival cohort was 0.16 copies per white blood cell for LV-WT-HSCT and 0.34 for LV-IIIA-HSCT.