Table 2. Top: Some average values reaction fluxes and transport rates in awake state, compute from 100,000 samples. Bottom: Input values for the simulations and mean results of a 100,000 steady states.
| Input | Awake | Excited | Inhibited |
|---|---|---|---|
| Blood flow | 0.55 | 0.75 | 0.55 |
| Oxygen arterial concentration | 9.3 | 9.3 | 9.3 |
| Carbon dioxide concentration | 23 | 23 | 23 |
| Glucose AV difference | 0.54 | 0.54 | 0.54 |
| Lactate AV difference | −0.18 | −0.18 | −0.18 |
| Reaction/transport |
Astrocyte |
Glutamatergic |
GABAergic |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Awake | Excited | Inhibited | Awake | Excited | Inhibited | Awake | Excited | Inhibited | |
| Glycolytic pyruvate | 0.22 | 0.28 | 0.29 | 0.28 | 0.37 | 0.31 | 0.22 | 0.27 | 0.30 |
| LDH (Pyr) | −0.11 | 0.17 | 0.00 | −0.16 | 0.25 | −0.09 | −0.14 | −0.19 | −0.03 |
| TCA | 0.12 | 0.12 | 0.30 | 0.41 | 0.60 | 0.29 | 0.14 | 0.13 | 0.21 |
| PC | 0.11 | 0.11 | 0.25 | — | — | — | — | — | — |
| Malic enzyme (c) | 0.12 | 0.12 | 0.35 | — | — | — | — | — | — |
| Malic enzyme (m) | — | — | — | ∼0 | ∼0 | ∼0 | 0.02 | 0.03 | 0.13 |
| PDH | 0.15 | 0.15 | 0.33 | 0.45 | 0.64 | 0.13 | 0.05 | 0.05 | 0.13 |
| OGC | 0.13 | 0.14 | 0.31 | 0.44 | 0.66 | 0.21 | 0.08 | 0.08 | 0.27 |
| AGC1 | 0.07* | 0.07* | 0.07* | 0.39 | 0.59 | 0.28 | 0.19 | 0.19 | 0.46 |
| OxPhos | 0.34 | 0.35 | 0.89 | 1.29 | 1.86 | 0.76 | 0.30 | 0.28 | 0.13 |
| GDA | — | — | — | 0.19 | 0.25 | 0.14 | 0.10 | 0.10 | 0.23 |
| GABA shunt | — | — | — | 0.19 | 0.25 | 0.14 | 0.07 | 0.07 | 0.10 |
| Glutamate efflux (net) | −0.30* | 0.45* | −0.11 | 0.30* | 0.45* | 0.11 | — | — | |
| GABA release (net) | −0.03 | −0.03 | −0.13 | — | — | — | 0.03 | 0.03 | 0.13* |
| Glutamine uptake (net) | −0.36 | −0.52 | −0.36 | 0.25 | 0.41 | 0.18 | 0.11 | 0.11 | 0.18 |
| Aspartate uptake (net) | 0.04 | 0.04 | 0.22 | 0.05 | 0.04 | −0.06 | −0.011 | 0.04 | −0.18 |
AGC, aspartate-glutamate carrier; AV, arteriovenous; GABA, gamma aminobutyric acid; GDA, glutamic decarboxylase; LDH, lactate dehydrogenase; OGC, oxoglutarate carrier; OxPhos, oxidative phosphorylation; PC, pyruvate carboxylase; PDH, pyruvate dehydrogenase; TCA, tricarboxylic acid.
All flux values are in μmol/g per minute. The TCA cycle rate is obtained from the flux of the FUM → MAL reaction. *indicates values that are entered as prior input values.