Figure 3.

Experimental design—effects of mass in the second injection. (Left) D-optimal inverse determinant of the reduced Hessian (det(HR)⁻¹) criterion as a function of injected mass. (Middle) Correlation between B_max with k_on and k_off as a function of injected mass. (Right) Sensitivity curves for k_on, k_off, and B_max in the mesial temporal cortex (MTC) in which the second injection consists of unlabeled mefway mass that occupies ∼75% of the available receptors. PET, positron emission tomography.