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. 2012 Apr 4;32(8):1559–1566. doi: 10.1038/jcbfm.2012.47

Figure 5.

Figure 5

TCDD exposure increases Bcrp- (A) and Mrp2-mediated transport (B). Capillaries were preincubated for 30 minutes without or with 5 μmol/L resveratrol (RES). TCDD was added to the medium. After 3 hours, BODIPY-prazosin or Texas red was added to the medium; capillaries were imaged after an additional hour. Each bar represents the mean value for 8 to 11 capillaries from a single preparation (pooled tissue from 10 rats); variability is shown as standard error bars. Statistical comparisons: ***significantly different from control, P<0.001. TCDD, 3,7,8-tetrachlorodibenzo-p-dioxin; Mrp2, multidrug resistance protein 2; Brcp, breast cancer-related protein.