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Typical time-activity curves (TACs) for the kinetic classes used in SVCA6 (A) and SVCA4 (B). TACs were scaled by subtracting from each time point the frame average and dividing by the frame standard deviation. SVCA4 uses only four kinetic classes and the curves are different because scaling is performed after brain extraction. HSB stands for high specific binding (i.e., binding to activated microglia). SVCA, supervised cluster analysis.
