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. 2012 May 16;32(8):1600–1608. doi: 10.1038/jcbfm.2012.59

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Copyright © 2012 International Society for Cerebral Blood Flow & Metabolism, Inc.

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Comparison of reference tissue V_b (A) and V_T (B) using box and whisker plots, including two-tailed T-test analysis for comparison between methods. Reference tissue time-activity curves (TACs) were based on manually drawn gray+white-matter cerebellum (CER), and those extracted automatically using SVCA4 and SVCA6. Data were taken from young controls (YC), old controls (OC), and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Note that all two-tailed T-tests were performed after removing the outliers (marked with open circles) shown in the figure.