. Author manuscript; available in PMC: 2012 Aug 17.

Published in final edited form as: Br J Ophthalmol. 2010 Oct 28;95(7):909–914. doi: 10.1136/bjo.2010.186924

Table 1.

Spectral-domain (SD) optical coherence tomography (OCT) retinal nerve fibre layer (RNFL) thickness measurement reproducibility

Authors	SD-OCT device (company)	Study design	Main finding
Leung et al¹⁸	Cirrus OCT (Carl Zeiss Meditec)	Comparison with TD-OCT (Stratus)	Intravisit repeatability of Cirrus OCT ranged between 5.12 and 15.02 μm, intervisit reproducibility ranged between 4.31 and 22.01 μm
			The intervisit variabilities of sectoral and mean RNFL thicknesses were lower in Cirrus HD-OCT compared with TD-OCT (Stratus)
Schuman¹⁹	Cirrus OCT (Carl Zeiss Meditec) RTVue OCT (Optovue)	Comparison with TD-OCT (Stratus)	SD-OCT had a significantly better repro- ducibility in most RNFL sectoral measurements than TD-OCT
			No statistically significant differences in overall mean RNFL reproducibility between SD- and TD-OCT
Vizzeri et al²¹	Cirrus OCT (Carl Zeiss Meditec)	Reproducibility in healthy and glaucomatous eyes	The CV and ICC for mean RNFL thickness were 1.5% and 0.96 in healthy eyes, and 1.6% and 0.98, in patient eyes
González-García et al²²	RTVue OCT (Optovue)	Reproducibility in healthy and glaucomatous eyes	The CV and ICC for mean RNFL thickness were 1.54% and 0.97 in healthy eyes, and 1.9% and 0.97 in patient eyes
Garas et al²³	RTVue OCT (Optovue)	Influence of various factors on reproducibility	The intrasession CV and ICC for mean RNFL thickness were 2.2% and 0.99 in undilated status
			Pupil dilation, age and experience in imaging examinations did not influence reproducibility in a clinically significant manner
Menke et al²⁴	3D OCT1000 (Topcon)	Intrasession, interobserver reproducibility in healthy eyes	The intrasession CV and ICC were 4% (operator 1), 4.2% (operator 2) and 0.90 3D-OCT RNFL thickness measurements in healthy volunteers showed good intra- and interobserver reproducibility
Shin et al²⁵	RTVue OCT (Optovue)	Reproducibility of two different scan modes, NHM4 and RNFL 3.45	The CV and ICC for mean RNFL thickness were 2.31% and 0.96 in NHM4 mode, 2.03 and 0.95 in RNFL 3.45 modes
			Both NHM4 and RNFL3.45 modes showed excellent measurement reproducibilities

CV, coefficient of variance; HD, high definition; ICC, intraclass correlation coefficient; NHM, nerve head map; TD, time domain.