Table 2.
Spectral-domain (SD) optical coherence tomography (OCT) retinal nerve fibre layer (RNFL) thickness measurement diagnostic capabilities
| Authors | SD-OCT device (company) | Study design | Main findings |
|---|---|---|---|
| Leung et al18 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | The AUC was 0.962 for SD- and 0.956 for TD-OCT |
| No significant difference was detected between the TD- and SD-OCT | |||
| Park et al31 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | The AUC was 0.962 for SD- and 0.956 for TD-OCT |
| SD-OCT showed a better glaucoma discrimination capability than TD-OCT in the early stages of glaucoma | |||
| Moreno-Montañés et al32 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | The AUC was 0.837 for SD- and 0.829 for TD-OCT |
| The sensitivity and specificity, and AUCs were similar between TD and SD-OCT | |||
| Cho et al33 | SD-SLO/OCT (OTI) | Comparison with TD-OCT (Stratus) | The AUC was 0.969 for SD- and 0.959 for TD-OCT |
| Li et al34 | RTVue OCT (Optovue) | RNFL and ONH parameters | The AUC for RNFL thickness was 0.816, and for the cup–disc vertical ratio 0.782 |
| Sehi et al35 | RTVue OCT (Optovue) | Comparison with TD-OCT (Stratus) | The AUC was 0.88 for SD- and 0.87 for TD-OCT |
| No significant difference was detected between the TD- and SD-OCT | |||
| Leung et al36 | Spectralis OCT (Heidelberg Engineering) | Comparison with HRT (Heidelberg Engineering) | SD-OCT RNFL measurement attained a higher sensitivity (AUC; 0.978) than HRT optic disc measurement (0.905) |
| Jeoung et al37 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | No significant differences between the AUCs for SD- (0.728) and TD-OCT (0.760) in discriminating preperimetric glaucoma |
| Sung et al29 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | SD-OCT demonstrated a higher sensitivity (63.6%) than TD-OCT (40.0%) in normative classification of mean RNFL thickness |
| Chang et al30 | Cirrus OCT (Carl Zeiss Meditec) | Comparison with TD-OCT (Stratus) | The sensitivity and specificity of various RNFL parameters using the Cirrus OCT for glaucoma with early to moderate visual field defects are excellent and are equivalent to Stratus OCT |
| Vizzeri et al28 | Cirrus OCT (Carl Zeiss Meditec) Spectralis OCT (Heidelberg Engineering), RTVue OCT (Optovue) | Detection of localised RNFL defect | All three SD-OCTs were able to detect localized glaucomatous structural damage seen in stereophotographs |
AUC, area under the receiver operating characteristic curve; HRT, Heidelberg retinal tomogaph; ONH, optic nerve head; TD, time domain.