Table 1.

Criteria used to determine whether models replicated age-related and distributional patterns of infection and antibody seen in cross-sectional and post-treatment field data

Pattern identified in field data	Criterion applied to model output	Source
Cross-sectional
Prevalence of infection by urine test	Prevalence of egg positives 5–80% for 6–14 year olds and for 15–34 year olds	Refs. 14, 44
Peaked age intensity curve	Maximum level of infection occurs between age of 6–23 years old	Refs. 7, 14, 16, 44
Reduced infection level in adults	Infection level in 24–34 year old age group < 40% of peak age group	Refs. 7, 14, 16, 44
Peak shift	Peak infection intensity is lower and occurs in the same or older age group when infection rate is halved	Ref. 12
Aggregated egg output	Standardized variance (SV) of mean egg output 2–60 for whole population, for 6–14 year olds and for 15–34 year olds	Refs. 14, 44
Antibody switch	Spearman’s ρ for association between two antibody responses < -0.2	Refs. 13, 14, 20
Antibody switch after age of infection peak	Initial (nonprotective) antibody response first falls below its midpoint value in the same or a later age group than peak infection	Refs. 13, 14
Post-treatment
Antibody switch after treatment	A2 is ≥200% and A1 is ≤ 50% of respective pre-treatment levels at both 18 and 36 wk post-treatment	Ref. 20