Fig. 2.

Control of HIV infection by A2-restricted Gag-p17-specific CTL. (A) Results of live virus ELISPOT assay carried out with E:T = 400:20,000. All data are representative of three independent experiments. Error bars, SD, P as calculated by Student's t test. (B) Correlation between mean fluorescent intensity of A2 chimera of HIV-IIIB-infected cells and mean spot-forming units. (C) Representative flow-based viral suppression assay results of selected HIV-IIIB-infected chimeric cell lines cocultured with A2 Gag-restricted CTL clones. CD8+ cells were gated out. (D) Percentage suppression of HIV-1-infected cells (p24 positive cells) compared with cultures incubated without A2 Gag-specific clones.