Table 2.

[³H]NCS-382 binding data from α4 and δ KO brain tissue

	GHB IC50 (pIC50 ± SEM; M)*	NCS-382 IC50 (pIC50 ± SEM; M)†	Bmax (pmol/mg protein)
δ−/−	2.12 ⋅ 10−6 (5.68 ± 0.06)	2.24 ⋅ 10−7 (6.70 ± 0.11)	10.1 ± 3.01
δ+/+	3.12 ⋅ 10−6 (5.51 ± 0.05)	2.65 ⋅ 10−7 (6.62 ± 0.10)	14.3 ± 2.93
α4−/−	1.22 ⋅ 10−6 (5.97 ± 0.16)	2.16 ⋅ 10−7 (6.67 ± 0.03)	12.2 ± 0.89‡
α4+/+	1.19 ⋅ 10−6 (5.94 ± 0.09)	2.20 ⋅ 10−7 (6.67 ± 0.06)	20.1 ± 1.90

*n = 3.

^†n = 5.

^‡P = 0.0056, unpaired Student t test.