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Inflammatome gene regulatory (Bayesian) networks and their predicted key drivers that are highlighted as large red nodes. The nodes in each network are the inflammatome signature genes and the directed links between them are derived from the causal networks reconstructed by integrating genetic and gene expression data in the corresponding cohort: (A) the human adipose IFA study; (B) the human liver HLC study. HCK, CD53, and TYROBP are the top drivers of both inflammatome subnetworks.
