Figure 1.

The EGFR signaling cascade.

Notes: Schematic representation of the EGFR signaling axis including its most important downstream targets. Molecular categories are as shown in the color scheme. A direct arrow represents direct interaction, dotted arrows represent translocation into different subcellular compartments, and blunted line represents inhibitory effects. The grey broken line represents the interface between cytoplasm and nucleus.

Abbreviation: EGFR, epidermal growth factor receptor.