Fig 1.

Diagram of M. tuberculosis isolate evaluation. This figure describes the breakdown of subjects and their isolates by category (screened subjects with baseline isolates, enrolled subjects with endpoint isolates, and community subjects with control isolates) included in the analysis and the degree of clustering and East Indian GD family representation in each. Baseline isolates were obtained from HIV-infected subjects when screened for the DarDar Vaccine Trial; endpoint isolates were obtained from enrolled HIV-infected subjects at the time of a tuberculosis diagnosis. Superscripts: a, uninterpretable results were mostly the result of mixed cultures caused by contamination or representative of a mixed infection; b, twelve duplicate results from nine subjects with multiple specimens were removed from the main analysis but included in the determination of polyclonal disease; c, includes one polyclonal disease subject with two isolates; d, includes five polyclonal disease subjects with two isolates each.