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Two-week in vitro potency of MK-5172 against gt1b replicon cells. Stable genotype 1b replicon cells were incubated in the presence of MK-5172 at 2, 5, or 10 nM or with a no-drug DMSO control for 2 weeks and in the presence of G418 (0.5 mg/ml) without MK-5172 for a third week. At the indicated time points, cells were harvested and replicon RNA was quantified by quantitative RT-PCR (qRT-PCR).
