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MK-5172 potency against a genotype/mutant panel of stable replicon cell lines
| Genotype/mutant | MK-5172 EC50 (nM)a |
|---|---|
| gt1b con1 | 0.5 ± 0.1 |
| gt1b con1 40% NHS | 7.0 ± 3 |
| gt1b Q41R | 1.8 ± 1.0 |
| gt1b F43S | 1.3 ± 0.1 |
| gt1b R155K | 0.3 ± 0.1 |
| gt1bA156T | 131 ± 35 |
| gt1b D168Y | 4.0 ± 0.8 |
| gt1a | 2.0 ± 1 |
| gt2a | 8.0 ± 4 |
| CC50 | >50,000 |
Values are means and standard deviations except for CC50, for which the value is only the mean.
