Table 3.
MK-5172 potency against a panel of HCV replication mutants
| Target | Genotype or mutation | EC50 (nM)a |
|||
|---|---|---|---|---|---|
| MK-5172 PI | HCV-796 NS5B NNI | MK-0608 Nucleoside | BMS790052 NS5a | ||
| None | gt1b con1 WT | 0.4 ± 0.1 | 4.7 ± 1.6 | 507 ± 106 | 0.002 ± 0.001 |
| NS5A | Y93H | 0.7 ± 0.3 | 9.6 ± 6.9 | 490 ± 360 | >3.5 |
| NS5B | C316Y | 0.4 ± 0.2 | 1,020 ± 240 | 220 ± 74 | 0.005 ± 0.004 |
| NS5B | S282T | 0.3 ± 0.1 | 9.4 ± 6.7 | >40,000 | 0.002 ± 0.001 |
a
Values are means and standard deviations. PI, protease inhibitor; NNI, nonnucleoside inhibitor. Bolded values indicate a potency shift.