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MK5172 concentrations in matched liver/plasma samples from HCV-infected chimpanzees treated with MK-5172
| HCV genotype | MK5172 concn (μM) ina: |
Liver/plasma ratio | |
|---|---|---|---|
| Plasma | Liver | ||
| gt1a | 0.002 | 0.85 | 425 |
| gt1b | 0.003 | 1.99 | 663 |
| gt1a NS3 R155K | 0.002 | 1.57 | 785 |
MK-5172 drug concentrations were determined from paired plasma and liver biopsy samples collected 12 h after the final dose.
