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Three mathematical models evaluated for piperacillin. The lines represent the median, 5th-percentile, and 95th-percentile of unbound piperacillin concentrations at steady state for piperacillin (3 g) administered for 4 h. Open circles represent observed piperacillin plasma concentrations. (A) Linear model; (B) Michaelis-Menten model; and (C) parallel first-order/Michaelis-Menten model.
