Table 4.
Optimal timing after the first dose and a steady-state dose as identified by D-optimal design
| Drug regimen | Optimal timing (h after dosage initiation) ofa: |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First dose | Steady-state dose | |||||||||||
| Piperacillin (4 g) administered for 30 min | 0.25 | 0.75 | 2.25 | 4.00 | 4.75 | 6.50 | 0.25 | 0.75 | 1.75 | 2.75 | 3.50 | 4.75 |
| Tazobactam (500 mg) administered for 30 min | 0.25 | 1.00 | 2.25 | 3.25 | 5.50 | 7.25 | 0.25 | 1.00 | 2.50 | 5.00 | 5.75 | 8.00 |
| Piperacillin (4 g)-tazobactam (500 mg) administered for 30 min | 0.25 | 1.00 | 2.25 | 3.75 | 5.25 | 6.75 | 0.25 | 0.75 | 2.00 | 3.75 | 4.50 | 6.25 |
| Piperacillin (4 g) administered for 4 h | 1.00 | 4.25 | 5.75 | 6.25 | 7.25 | 8.00 | 0.25 | 1.00 | 4.25 | 5.00 | 6.00 | 7.75 |
| Tazobactam (500 mg) administered for 4 h | 0.75 | 2.25 | 3.50 | 4.25 | 7.00 | 8.00 | 0.50 | 2.25 | 3.75 | 4.25 | 6.25 | 8.00 |
| Piperacillin (4 g)-tazobactam (500 mg) administered for 4 h | 1.00 | 3.25 | 4.5 | 5.25 | 7.25 | 8.00 | 0.25 | 1.75 | 4.00 | 4.75 | 6.00 | 7.75 |
a
Values in bold represent a composite time point for sampling combinations of piperacillin at 4 g and tazobactam at 500 mg.