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Selective inhibition of ATP synthesis by compounds 1 to 3 and reference compounds (average ± SD)
| Compound | ATP synthesis IC50 (μg/ml) |
||
|---|---|---|---|
| S. aureus | E. coli | Mitochondria | |
| 1 | 1.4 ± 0.5 | 7 ± 0.4 | 29 ± 2 |
| 2 | 2.5 ± 0.7 | 8 ± 0.6 | 27 ± 1.6 |
| 3 | 2.7 ± 0.1 | 9 ± 0.6 | 23 ± 2.2 |
| DCCD | 0.9 ± 0.2 | 1 ± 0.1 | 0.2 ± 0.01 |
| Oligomycin | 5.6 | 7 ± 0.7 | 6 ± 0.6 |
