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Schematic representation of the ergosterol biosynthetic pathway in C. glabrata showing the structure of sterols used in the present study. (A) Classical pathway; (B) sterol intermediates that accumulate following azole inhibition of sterol 14α-demethylase (ERG11 protein); (C) end product ergosterol, the binding target of polyene antifungals; (D) cholesterol and related sterol intermediates.
