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. 2012 Aug;56(8):4078–4086. doi: 10.1128/AAC.00218-12

Table 3.

Pharmacokinetic parameters of tulathromycin in lung tissue homogenates and plasma samples of mice treated with a single s.c. injection of tulathromycin at 7 and 28 mg/kg body weight

Pharmacokinetic parametera Value for group
T-28
T-7
T-7-LPS
T-7-LPS-CP
Plasma LH Plasma LH Plasma LH Plasma LH
HL_lambda_z (h) 18.1 112 13.5 82.0 16.5 213 17.6 144
Tmax (h) 0.50 1.00 0.50 0.50 0.50 0.50 1.00 1.00
Cmax (ng/ml) 11,700 27,900 3,300 4,410 6,790 3,940 6,920 5,500
Clast (ng/ml) 13.6 3,860 15.4 1,020 7.82 1,060 6.48 750
AUClast (h · ng/ml) 152,000 869,000 31,000 246,000 52,600 199,000 88,100 199,000
AUCinf_obs (h · ng/ml) 152,000 1500,000 31,200 378,000 52,800 487,000 88,300 356,000
AUMClast (h · h · ng/ml) 599,000 45000,000 274,000 15700,000 252,000 8670,000 259,000 9330,000
MRTinf_pred (h) 4.16 148 8.91 138 4.99 287 3.03 177
AUC(0–144) LH/plasma ratio 5.77 7.95 3.79 2.26
a

Dispersion data of the PK parameters are not presented because PK parameters were estimated based on least-square means derived from the naïve pooling from each sample point. LH, lung homogenate.