Table 3.
Pharmacokinetic parameters of tulathromycin in lung tissue homogenates and plasma samples of mice treated with a single s.c. injection of tulathromycin at 7 and 28 mg/kg body weight
| Pharmacokinetic parametera | Value for group |
|||||||
|---|---|---|---|---|---|---|---|---|
| T-28 |
T-7 |
T-7-LPS |
T-7-LPS-CP |
|||||
| Plasma | LH | Plasma | LH | Plasma | LH | Plasma | LH | |
| HL_lambda_z (h) | 18.1 | 112 | 13.5 | 82.0 | 16.5 | 213 | 17.6 | 144 |
| Tmax (h) | 0.50 | 1.00 | 0.50 | 0.50 | 0.50 | 0.50 | 1.00 | 1.00 |
| Cmax (ng/ml) | 11,700 | 27,900 | 3,300 | 4,410 | 6,790 | 3,940 | 6,920 | 5,500 |
| Clast (ng/ml) | 13.6 | 3,860 | 15.4 | 1,020 | 7.82 | 1,060 | 6.48 | 750 |
| AUClast (h · ng/ml) | 152,000 | 869,000 | 31,000 | 246,000 | 52,600 | 199,000 | 88,100 | 199,000 |
| AUCinf_obs (h · ng/ml) | 152,000 | 1500,000 | 31,200 | 378,000 | 52,800 | 487,000 | 88,300 | 356,000 |
| AUMClast (h · h · ng/ml) | 599,000 | 45000,000 | 274,000 | 15700,000 | 252,000 | 8670,000 | 259,000 | 9330,000 |
| MRTinf_pred (h) | 4.16 | 148 | 8.91 | 138 | 4.99 | 287 | 3.03 | 177 |
| AUC(0–144) LH/plasma ratio | 5.77 | 7.95 | 3.79 | 2.26 | ||||
a
Dispersion data of the PK parameters are not presented because PK parameters were estimated based on least-square means derived from the naïve pooling from each sample point. LH, lung homogenate.