Fig 2.

Longitudinal analysis of systemic cIFN-α in hamsters treated with DEF201. Hamsters (n = 3 per group) were treated with the indicated doses of DEF201, the EV control virus, or PBS. (A, B) Serum concentrations of cIFN-α were determined by ELISA (mean and standard deviation of replicate wells). (C to F) Body weights were measured every 3 days. Individual solid or hashed lines in each graph represent data obtained from individual animals. The values for the low-dose (A, C) and high-dose (B, D) DEF201-treated hamsters are linked (similarly formatted lines represent the same animal) to show correlation between high cIFN-α concentrations and weight loss. cIFN-α protein was undetectable in hamsters treated with the negative-control EV virus or PBS (data not shown).