Table 2.
Antibacterial and macromolecular inhibitory concentrations of LFF571
| Test agent | IC50 (μg/ml ± SD)a |
Antibacterial concn (μg/ml)b | |
|---|---|---|---|
| [3H]leucine | [3H]NAGc | ||
| LFF571 | 0.06 ± 0.004 (n = 5) | >1 (n = 5) | 0.03 |
| Tetracycline | 10.2 ± 4.3 (n = 5) | >32 (n = 5) | 8 |
| Vancomycin | >32 (n = 5) | 2.6 ± 1.9 (n = 6) | 4 |
a
Values represent means ± standard deviation (SD).
b
Antibacterial concentrations were determined using the same medium and inoculum with which the macromolecular synthesis experiments were performed. Strain NB95026 was used for all assays.
c
NAG, N-aeetylglucosamine.